The concept of PAMD is to seek drug candidates among compounds existing in our body after orally taking TCM herbs, of which are with proven clinical benefits and demonstrated safety profiles. Given the fact that compounds absorbed by our body is less than 1% of those contained in TCM formula and many of them are metabolites of original active ingredients, PAMD strategy drastically improved efficiency in finding lead compounds from TCM for development of new single compound drugs as well as compound-combinations derived from TCM formulas. With the PAMD strategy, a series of proprietary drug candidates and products have been developed and some of them are near clinical stage or already on the market.